Thermo Scientific ProSightPC software, the first stand-alone software for analyzing top-down proteomics data, has been enhanced to support all high-mass-accuracy, high-resolution MS/MS proteomics experiments. ProSightPC™ 2.0 enables high-throughput processing of accurate-mass MS2 data, whether from top-down, middle-down or bottom-up experiments, and facilitates the characterization of proteins with known PTMs.
Product Detail
ProSightPC 2.0 software includes five different search modes:
Accurate Mass
Biomarker
Sequence Tag
Single Protein
Gene Restricted
These five different search modes can be used to determine exact protein sequences, including modifications and alternative splicing. The software can process fragmentation from ECD, IRMPD or CID to determine the protein sequence. The proprietary ProSight Warehouse allows users to import FASTA databases and shotgun annotate these databases with all possible modifications. ProSightPC software also includes the Sequence Gazer that helps users to validate their search results and verify that they have the correct sequence.
ProSightPC 2.0 software:
Enables high-throughput processing of all accurate-mass MS2 data, whether from top-down, middle-down or bottom-up experiments.
Includes the characterization of proteins with known PTMs
Top-down sequencing using ProSightPC provides protein sequence information including:
Exact sites of modifications
Truncated proteins, splice variants and biomarkers
Exact confirmation of bottom-up experiments
Offers multiple search modes and supports ECD, IRMPD, and CID fragmentation to determine the protein sequence
Proprietary ProSight Warehouse allows searches for all PTMs and for splice variants
Uses shotgun annotation to find all possible PTMs
Can import any FASTA databases
Sequence Gazer helps users probe their data manually and add, remove or change modifications to look for better data fit
Designed for use with the Thermo Scientific LTQ FT series and LTQ Orbitrap series hybrid mass spectrometers
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