| Please send
Comments & Suggestions to
criticalmass@thermo.com |
| MSeminar |
|
 |
Featuring the following LIVE & Recorded
Seminars:
- Introduction to the Finnigan ProteomeX LTQ:
Methods & Applications
- Finnigan LTQ FT: The Most
Advanced LC-MS and MS/MS System Ever
- Finnigan TSQ Quantum
for Quantitation: An Introduction
- Environmental
Applications for the Finnigan TSQ Quantum: Chloramphenicol,
Perchlorate & CDFA
- Top Down Proteomics using the
Finnigan LTQ FT
- Optimizing the Finnigan TSQ Quantum for
high sensitivity: Part 1
- Increasing Confidence Levels of
Protein ID on the Finnigan LTQ FT
- Optimizing the Finnigan
TSQ Quantum for high sensitivity: Part 2 and more...
Get
the latest schedule at www.thermo.com/mseminar
!! |
| Higher
Confidence Level for Protein ID |
|
 |
With the fast growth of protein databases, there is
also an increased demand for highly sophisticated mass
spectrometry (MS) based methods for protein identification
(protein ID).
Several aspects of experimental set-up can
help to reduce or eliminate false positive and false negative
results from protein mixture analyses.
1) Mass
Accuracy: The mass of a peptide after digestion should be
measured with the highest possible mass accuracy. The higher
the accuracy of the result, the faster the database search
will be and the lower the probability of a false positive or
negative protein ID. MS/MS fragmentation information is still
required to confirm the database search result and identify
the location of any post-translational modifications
(PTMs).
2) Sequence Coverage: Proteins should
be...more |
| Quantitation?
Think Quantum |
|
 |
The
Finnigan TSQ Quantum product line is the most sensitive series
of triple quadrupole mass spectrometers available in the
market today, capable of consistently producing linear dynamic
ranges for quantitative assays. [Read
Article]
Previous: Robustness
and the Finnigan TSQ Quantum
Next:
H-SRM on the Finnigan TSQ
Quantum |
|
| News: Video
Clips, Downloads, Seminars & more... |
 |
-
Introduction to the most sensitive and advanced Triple Quad
[Video
Clip].
- Rapid Accurate Protein Identification [Video
Clip].
- Download
Proteomics Pioneers Vol.4. including interviews with experts
Alexander Kurosky, John Fenn, Bill Lane, Kenneth Standing,
Daniel Liebler, Matthias Wilm, Catherine Costello, ruedi
Aebersold, Angelika Gorg, Roland Annan, Peter Roepstorff and
Peter James.
- Attend
the European Proteomics Seminar Series.
- Attend
the Montreux LC/MS User Group Meeting. |
| |
| Proteomics
Applications |
 |
-
"Phosphoproteomic Analysis of the Developing Mouse Brain" By
Researchers at the Department of Cell Biology at Harvard
Medical School using a Finnigan LCQ Deca XP [Read
Paper]
- Characterization of Protein Glycosylation
using ESI Chip Static Nanospray IonTrap [Download]
-
Data Dependent Neutral-Loss Mass Spectrometry for the
Identification of Protein Phosphorylation [Download]
More
Proteomics Applications... |
| |
|
|
| Software |
 |
- Your
opinion matters! We strive every day to improve the usability
of our software and provide features that you really need.
Please take a moment to visit www.thermo.com/ms-software
and tell us what you want. In return, you will be entered in a
drawing to win a free palmOne(TM) Treo(TM)
smartphone.
- Mass Frontier 4.0 Service Release 2
(Released Sep 29, 2004): Go to www.highchem.com,
click on 'Downloads' and follow the
instructions.
|
| |
| Small
Molecule Applications |
 |
-
Determination of Choline and Its Metabolites using a Finnigan
LTQ Linear Ion Trap Mass Spectrometer [Download]
-
Accurate Mass Measurements of Pharmaceutical Compounds and
Peptides on a Chromatographic Time Scale Using the Finnigan
TSQ Quantum Ultra AM [Download]
-
Analysis of a Verapamil Microsomal Incubation using Metabolite
ID and Mass Frontier [Download]
-
In-Vitro Metabolism Studies Using Data-Dependen LC/MSn [Download]
More
Small Molecule Applications... |
| |
|
| Trap Talk:
Neutral Fragment Filter |
|
 |
The
neutral fragment filter is one method to detect specified
neutral losses in MSn experiments. It steps through each MSn
scan and plots the presence of components showing a specified
neutral loss from the parent. Figure 1 shows the base peak
trace from a mixture of three digested proteins under Data
Dependent MS2 conditions. The lower trace shows the neutral
loss trace of m/z 49, which suggests the presence of two major
phosphorylation sites. [Read
Full Article]
Previous: Dynamic
Exclusion |
|
|
|
| Through the Customer's
Eyes |
"[Finnigan]
LTQ data is exceptional...faster scan speed and greater
sensitivity in MS/MS mode improves protein
coverage"
-- Tina Gatlin, Ph.D.
Associate
Director, Proteomics
The Institute of Proteomics
Research
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|
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| For additional
information |
Please send Comments and
Suggestions to criticalmass@thermo.com
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